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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Efficient Pretreatment of Rice Straw by Combination of Screw- Press and Ionic Liquid to Enhance Enzymatic Hydrolysis) ผู้เขียน: Malinee Sriariyanun, Qingqi Yan, Kraipat Cheenkachorn, Theerawut Phusantisampan, Michael Modigell สื่อสิ่งพิมพ์:pdf AbstractThe increasing value of lignocellulose-based biorefining has attracted interest from research and development organizations worldwide to find an efficient pretreatment method for dissociating the recalcitrated structure of lignocellulosic biomass. Nowadays, different pretreatment processes have been developed, including chemical, physical or biological processes. In this study, the effects of pretreatment by a combination of screw-press and four different types of ionic liquids (ILs) to enhance the saccharification efficiency were observed to select the best IL. The inhibition effects of ILs were monitored based on the relative cellulase activities, and the results showed that each IL had a different inhibition degree. Based on pretreatment efficiency and inhibition properties, 1-allyl-3-methylimidazolium chloride, [AMIM]Cl, was selected for the optimization experiment using response surface methodology with a three-factor Box-Behnken design (consisting of ionic liquid concentration, reaction temperature and retention time). Under the best conditions (150 ?C reaction temperature, 50% concentration), 68.26% of recovered sugar could be achieved from the pretreated rice straw. A mathematical model represented the statistically significant (P < 0.05) effects of two treatment parameters (temperature and concentration) on the saccharification efficiency with a coefficient of determination of 0.7460. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Association between Haplotype Tagging Single Nucleotide Polymorphisms of the ret proto-oncogene (RET) and Hirschsprung Disease in Thais) ผู้เขียน:Theerawut Phusantisampan, Surasak Sangkhathat, Weeradej Meeinkuirt, Malinee Sriariyanun สื่อสิ่งพิมพ์:pdf AbstractHirschsprung disease (HSCR) is one of several considerably complex diseases. Several HSCR susceptibility loci have been reported through genome-wide association studies. However, haplotype tagging single nucleotide polymorphisms (htSNPs) of the ret proto-oncogene (RET) has been identified in the past as being associated with an increased risk for HSCR. This study genotyped 10 single nucleotide polymorphisms (SNPs) of the RET in 68 patients with HSCR and 120 controls using TaqMan SNP genotyping assays and restriction fragment length polymorphism. However, haplotype analysis of the RET was likewise associated with the disease which has been suggested to be more powerful than individual SNP analyses. The haplotype analysis was carried out using Haploview software. The results showed that htSNPs, located in the intron 1 of the RET, strongly associated with HSCR (odds ratio 3.64, 95% confidence interval 2.24–5.92, P < 0.0001). These findings suggested that RET plays a role in the pathogenesis of HSCR in the Thai population. |
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